What is the difference between CML (chronic myelogenous leukemia) become AML (acute myelogenous leukemia) and CMMoL (chronic myelomonocytic leukemia)?

 

The three diseases you mention are 3 distinct entities.

CML or chronic myelogenous leukemia is a disease in which patients have too many mature white blood cells. It is considered a myeloproliferative disorder-a condition in which the bone marrow makes too many cells. This disease is diagnosed by the presence of either the Philadelphia Chromosome or the gene made by the Philadelphia chromosome, called bcr-abl. New treatments, which target this abnormal gene, have been developed. It is considered in the list of possible diagnoses, this chromosome is looked for so that appropriate therapy is not missed.

AML or acute myelogenous leukemia is a disease in which patients have too many immature white blood cells in their bone marrow that are not capable of maturing properly. These immature cells act very rapidly and can cause life-threatening problems if the disease is not treated promptly.

CMMoL or chronic myelomonocytic leukemia is a disorder of the bone marrow where the bone marrow is making too many white blood cells called monocytes. The bone marrow appears myeloproliferative but the cells that it makes are not normal mature cells and do not function properly. This disorder is called a myelodysplatic disorder (funny looking bone marrow). Its progression and outcome is variable and can be predicted to some degree by the blood counts and bone marrow findings.

 

https://www.oncolink.org/frequently-asked-questions/cancers/leukemia/general-concerns/what-is-the-difference-between-cml-chronic-myelogenous-leukemia-become-aml-acute-myelogenous-leukemia-and-cmmol-chronic-myelomonocytic-leukemia

 

Scientists reveal how immune system tags Toxoplasma capsule

 

By

Scientists at the Francis Crick Institute have discovered how the host immune system deals with the prolific Toxoplasma parasite as it attempts to camouflage itself by hiding inside a capsule called a vacuole in human cells.

 

For the first time, they’ve revealed how a protein called ubiquitin tags the vacuole hiding Toxoplasma. The cell’s acidification system then destroys it.

Eva Frickel, the research group leader at the Crick who led the work, explains: “The parasite Toxoplasma gondii resides inside a vacuole in the cells of the organism it infects. The vacuole provides a safe haven for the parasite where it can multiply and cause damage to the host. Until now, it was unclear what defence mechanisms human cells deploy to the vacuole to clear and eliminate Toxoplasma. We have found that a human protein called ubiquitin tags the vacuole for destruction via the cell’s acidification system.”

Toxoplasma gondii is a parasite found almost everywhere. It is in soil and unwashed food, but its most important host is the cat. It causes an infection called toxoplasmosis that can cause miscarriage and is especially damaging to people who have a weakened immune system, others never know they’ve been infected.

The team used immunofluorescent microscopy to visualise each step in vacuole destruction. They learnt how a ubiquitin protein tags the vacuole and then attracts other proteins that stick on and allow it to join with an acidic compartment called the lysosome. This then destroys the vacuole and parasite.

“This work is the first demonstration of how ubiquitin tagging leads to vacuole-lysosome fusion in human cells infected with Toxoplasma,” Eva says. “Until now, it was thought the vacuoles were not susceptible. Mouse studies have shown a different route to fusion between the vacuole and lysosome. This raises questions for further studies on how vacuolar-lysosomal fusion in human cells happens and why the human cellular immune response is different from the mouse.”

Eva’s research team explores how react to Toxoplasma and what it is that makes it one of the most successful on the planet. There is no vaccine to protect against Toxoplasma infection or medicine that kills the parasite.

Eva talks about their work and shares images from the progress they are making in research in the Crick’s first public exhibition (above). How do we look? is a collection of scientific images that could be mistaken for works of art though each has been created by a scientist to solve a research problem.

Read more at: https://phys.org/news/2017-01-scientists-reveal-immune-tags-toxoplasma.html#jCp

Immune disorders impact student lives

By Hannah Lathen

_______________________________

SE student Janna Gentry lives with a mother who has Crohn’s disease and lupus, causing her to have stomach ulcers and inflamed joints.

Online student Laken Reeder has Sjogren’s syndrome, causing extreme pain and difficulties with eating.

TCC students are fighting hidden and misunderstood battles with autoimmune diseases. Even though they affect 1 in 6 people, many do not understand what they are or that they exist.

An autoimmune disease occurs in the body when one’s immune system starts attacking healthy cells. Instead of protecting the body from foreign invaders, the system starts hurting organs.

autoimmune_sjogren's_plasma_research

What is Keystone virus? Zika’s Cousin has now infected the first human!!

Zika Virus Has a New Competitor

PMR-KeystoneZika-v1 (1)

Another mosquito-borne virus, the Keystone virus, might pose a risk to people, specifically those in Florida.

A confirmed human case of Keystone was recently reported in the medical journal Clinical Infectious Diseases. Research author J. Glenn Morris suggested Keystone cases could be “fairly common in North Florida,” but he said this is the first confirmed case, possibly because patients are rarely tested for the virus.

Here’s what you should know about the Keystone virus:

When was it found?

The virus was first discovered in the Tampa Bay-area in 1964. Since then, animal cases (squirrels, raccoons and deer) have been found from Texas to the Chesapeake Bay.

How do you catch it?

The virus is transmitted by mosquito bites, usually bites from aedes atlanticus.

What are the symptoms?

Symptoms might include a rash, mild fever and encephalitis, brain inflammation.

How many people have it?

University of Florida researchers recently said a 16-year-old boy was the first human case of the Keystone virus. The teen did not suffer from brain swelling, but did have a fever and rash. The case was identified because doctors thought the teen might be suffering from the Zika virus during a known outbreak. The laboratory tests they collected from him for Zika testing led them to the Keystone discovery. The Florida Department of Health told USA TODAY there was another recorded case of the virus in a young child from Sarasota in 1964.

Is it related to Zika?

The aedes atlanticus mosquito, a cousin to the Zika-spreading aedes aegypti mosquito, is most well-known for carrying the Keystone virus. Aedes infirmatus mosquitos as well as other aedes and culex species have also known to carry the virus, the Florida Department of Health said.

Is there a cure?

There’s no specific treatment plan for the virus in humans.

How can we prevent it?

The only known way to prevent the virus is to avoid mosquito bites. The Environmental Protection Agency recommends using insect repellent, wearing long-sleeve shirts and pants, staying inside air-conditioned areas and using screens on windows and doors to prevent bites. In addition to these tips, the Florida Department of Health also suggests draining standing water, such as rainwater collected in garbage cans or pool covers.

Back in April, before the height of mosquito season, Bill Gates devoted a whole week of his blog, appropriately named ‘Mosquito week’, warning and educating people on the dangers of mosquitos.  This a great read to educate yourself and to learn about how a tiny African kingdom named Swaziland has developed a well-coordinated malaria program—including a robust surveillance and control system—that has helped reduce the number of cases in the country by more than 90 percent since 2002. Now, Swaziland aims to eliminate malaria entirely within its borders by 2020. (please see the gates notes link below to learn more)

What will the case be for the U.S.A. in 2020 and what will it look like since new cases are being discovered each year, bringing the number of mosquito species to over 3,000 in the world, of which 176 of them can be found in the United States.

PMR-MosquitoGraphic-v1

references;

Kyle Berard of Plasma MedResearch located in Boca Raton, FL

USA TODAY NETWORK Ashley May, USA TODAY Published June 25, 2018

https://www.gatesnotes.com/Health/Mosquito-Week-2018

https://www.gatesnotes.com/Health/Buzz-Kill

 

 

 

 

 

 

 

 

 

10 Signs Your Thyroid Isn’t Working

The thyroid, a butterfly-shaped gland located at front of our neck below the Adam’s apple, is a small but very important gland that releases hormones that have a huge impact on metabolism, among other processes. According to the American Thyroid Association, about 20 million Americans suffer from some form of thyroid malfunction, yet 60 percent don’t realize that they even have a problem. This makes realizing that the thyroid is malfunctioning really important.

Bright Side brings to you 10 signs that indicate that your thyroid might be acting up and it’s time to pay the doctor a visit. Don’t miss our important bonus at the end.

 

Dry, scaly and thick skin

 

Hypothyroidism leads to the calcification of the skin, causing it to appear thick, very dry, and scaly in texture.

Hair loss/thinning hair

Hair growth depends on the proper functioning of the thyroid gland. Changes in the level of the hormone produced by the thyroid gland can lead to changes in hair growth. Excessive production of the hormone can cause the hair to become thin all over the scalp while underproduction of the hormone can lead to hair loss

 Unusual bowel activity

 

Thyroid hormones play a role in regulating the bowel movement. An underactive thyroid can cause constipation, while an overactive thyroid can result in frequent bowel movements.

Depression/sudden anxiety

If you have been feeling anxious or unsettled lately, there’s a chance that your thyroid gland has been acting up. Overproduction of thyroid hormones results in more brain stimulation causing patients to feel jittery or anxious. Underproduction of the hormone has the opposite effect, it makes the patient feel depressed and tired.

Feeling unusually cold/unusual sweating

 

The thyroid gland is like a thermostat for our body in the sense that it regulates body temperature. If the hormone production gets beefed up it unusually increases the body’s metabolism causing people to feel overly warm and sweaty. If there is a deficiency of the thyroid hormone in the body the patient might be prone to having low body temperatures and cold intolerance.

 

 

Thyroid hormones are responsible for regulating the body’s metabolism. Lower than normal production of the hormone can significantly decrease metabolism and calorie burning abilities of the body causing you to gain weight, while over secretion of it will make you lose weight abruptly.

Irregular periods

 

If you are experiencing period problems, improper thyroid functioning might be the culprit. A lack of enough hormones will make the periods heavier, longer, or cause them to occur closer together while an abundant production of the hormone might make your periods lighter or cause them to occur further apart.

Brain fogging/difficulty concentrating

If your thyroid isn’t working properly, neither is your brain. An underactive thyroid can cause subtle memory loss while an overactive thyroid can make it difficult to concentrate.

Neck discomfort or enlargement

 

Both overproduction and underproduction of the thyroid hormone can lead to the enlargement of the thyroid gland causing the neck to appear swollen.

Changes in heart rate

Under secretion of the thyroid hormone can cause the heart to beat slowly, whereas hyperthyroidism causes a fast heartbeat.

Bonus: Who is at a greater risk?

 

  • Women more than men
  • Women over 60 years of age
  • People with a family history of thyroid related problems

Neck check for thyroid disorder:

Tip your head back and swallow. Examine your neck around the Adam’s apple and the area above your collarbones. If you feel lumps or bulges, see a doctor.

 

Sources: https://brightside.me/inspiration-health/10-signs-your-thyroid-isnt-working-515510/

 

 

Plasma Med Research - Get Paid to Donate Plasma Clinical Studies

 

 

What are the Differences between Crohn’s Disease, Ulcerative Colitis and IBD (Inflammatory Bowel Disease)

Article Source: http://managedigestion.com/what-are-the-differences-between-crohns-disease-uc-and-ibd/

 

Ulcerative Colitis and Crohn’s Disease

Ulcerative Colitis and Crohn’s disease are both Inflammatory Bowel Diseases affecting the bowel and colon. The common symptoms of these diseases are weight loss, severe abdominal pain, bloody diarrhea, and fatigue.

Crohn’s Disease and Ulcerative Colitis are found among many Americans. Symptoms of these conditions are abdominal pain, exhaustion, weight loss, and bloody diarrhea which can result in anemia. This has severe effects on the colon and bowel and can result in irritable bowel syndrome.

Ulcerative Colitis (UC) mostly attacks the mucosa and submucosa in the large intestine. It occurs normally in young adults starting from the age of 10 to 19 or 20 years old, irrespective of sex. Although the exact cause of this disease is not known, it is mostly attributed to infectious, immunological issues, nutritional and psychogenic related conditions, and both physical and emotional factors. Stress can be a major factor in the worsening of the illness. The presence of this disease may also be influenced by genes and environmental elements.

Ulcerative Colitis is usually indicated by frequent diarrhea. In acute cases, bloody diarrhea and severe pain and cramps in the abdominal region are major symptoms. This can also result in swelling of the abdomen. These conditions may result in anemia. The reduced intake of food and irritable bowel syndrome may bring down the water level and electrolytes in the body. Fever, weight loss, anorexia, and vomiting are the other features of this bowel disease.

Crohn’s Disease is more or less similar to UC. In fact, there are so many similarities between the two that sometimes it becomes difficult to differentiate between the two diseases. The main difference, however, is that Crohn’s does not attack the rectum, whereas Ulcerative Colitis does. Another major difference is that while UC affects only the mucosa and submucosa of the intestinal region, Crohn’s affects the muscularis propria in addition to the other two. Crohn’s Disease typically causes fistulas and strictures while UC results in deadly megacolon and if left untreated can even lead to colonic carcinoma. Due to constant inflammation and regeneration of the colonic wall, there appears a thickening of the bowel wall in Crohn’s Disease. In the case of UC however, the ulcerations made by the intestinal tract cause deep recesses or notches creating the appearance of pseudopolyps.

Inflammatory Bowel Disease (IBD)

However, an X-Ray can help differentiate between the two inflammatory bowel diseases. Although both classified as irritable bowel syndrome, the manner of treating ulcerative colitis is different from that of treating Crohn’s Disease even if some medications may be used for both. While diet plays a major role in Crohn’s, UC doesn’t seem to be affected much by diet.

 

Find out how you can help medical research and contribute to finding cures by contacting PlasmaMed through our website: www.plasmamedpatients.com/contact 

The A – Z of The Ultimate Cheat Sheet On Ulcerative Colitis

Article Source: http://managedigestion.com/z-ultimate-cheat-sheet-ulcerative-colitis/

 

What is it?

The word ulcerative colitis literary means inflammatory disease of the large intestine, characterized by the formation of the ulcers. Thus ulcerative colitis belongs to the group of disorders called Inflammatory Bowel Disease (IBS).

 

 

What causes it?

Perhaps no one would be able to say the exact cause of the disease. Most probably it is a combination of three things: environmental factors, genetics, and autoimmunity. Genetics means that there could be family history, and the person may inherit the collection of weak genes that increase the risk of disease. However, the disease has to be triggered by some changes in environment like some stressful condition, infection, food poisoning. Genetics and environment triggers cause the immune system to behave in wrong way, leading to the disease. The local immune system in the intestine starts to overreact to the infections or microbes thus leading to severe local inflammation, that may further erode to give rise to ulcers.

 

What are the symptoms?

It would start with the symptoms related to the disease of the large intestine, that is chronic diarrhea that would last for weeks or even months, and most treatments would not help enough. Blood in stool is common due to ulceration of large intestine or area near the rectum. Other symptoms would be abdominal cramping, pain in the rectum (pain would come and go), weight loss, chills, abdominal bloating, dehydration. If left untreated, many other symptoms of malnutrition may occur.

The disease is characterized by the flares and remissions, that is times when you may feel utterly sick, followed by the intervals of relative calm.

 

What are the tests?

There is the whole array of tests available. The doctor would often start with stool and blood test, not only to diagnose ulcerative colitis, but also to rule out other similar diseases. Colonoscopy may help to visualize the colon, and if needed take samples of tissue for histological examination. Abdominal CT scan, MRI, X-ray.

What needs to be done?

It is a condition that must be treated under the supervision of a doctor as it needs more than symptomatic care. The doctor would often use anti-inflammatory therapy by using amino-salicylates, corticosteroids, or immunosuppressants. Some cases may require surgical treatment.

 

What should I eat?

When it comes to diet, avoid high-fat food. Drink lots of liquids including coconut water, have more of ripe banana, ripe papaya, boiled apple, cabbage, carrots, and curd. Avoid (during flares) dairy products, high fiber food, alcohol, cut down on caffeine and carbonated beverages.

What can prevent it?

Change lifestyle, make significant changes to diet, avoid stressful conditions.

What are the dangers?

It increases the risk of some health conditions. Bones become weaker due to osteoporosis, in teenagers it may decrease the growth and development, even adults may lose too much body weight. It may cause disease of bile duct called sclerosing cholangitis, rare but life-threatening complication like megacolon due to trapping of gasses (increased risk of rupture), and finally, it increases the risk of bowel cancer.

 

Find out how you can help medical research and contribute to finding cures by contacting PlasmaMed through our website: www.plasmamedpatients.com/contact